子宫损伤后妊娠不良结局的临床诊治方案优化研究

国家重点研发计划

1000

2024.12-2027.11

王谢桐

利用滋养层类器官探讨羟氯喹调控CXCL12/CXCR4轴改善抗磷脂抗体介导胎盘损伤的作用及机制

国家自然科学基金

49

2024.01-2027.12

王谢桐

优化严重产后出血诊治策略的研究（严重产后出血围分娩期临床管理研究）

国家重点研发计划

460

2021.12-2024.11

王谢桐

胎儿水肿的病因学诊断与宫内干预及预后评估

国家重点研发计划

320

2018.07-2020.12

王谢桐

建立出生人口队列开展重大出生缺陷风险研究。

国家重点研发计划

251

2017.09-2021.12

王谢桐

双胎妊娠母胎不良结局发生机制、预测及干预策略研究

国家重点研发计划子课题

40

2023.12

孟金来

CD24/Siglec-10调控蜕膜巨噬细胞极化参与子痫前期发生的作用及机制研究

山东省自然科学基金面上项目

10

2025.01-2027.12

孟金来

基于蛋白组学和机器学习构建子痫前期早期预测模型的研究

济南市科技发展计划

10

2024-12

孟金来

红细胞叶酸与妊娠期合并症、并发症及妊娠结局的关联性研究

山东省医学会横向课题

10

2022-2025

孟金来

阿托西班抑制宫缩的真实世界研究

横向课题

12

2023.11

孟金来

基于压脉带环扎的子宫缝合技术在产后出血中的应用

山东省第十二批适宜卫生技术推广项目

1

2020.12.14

孟金来

胎盘外泌体miR-320c调节血管内皮细胞参与子痫前期发病的机制研究

国家卫生健康委生育调控技术重点实验室

5

2022.01-2023.12

孟金来

危重孕产妇救治典型病理分析研究。

国家卫健委妇幼司课题

3

2023.03-2024.06

彭文

产后子宫下段出血的流行病学及对策研究。

济南市临床医学科技创新计划

20

2022.07.1-2025.06.30

王红梅

前瞻性多中心胎儿膈疝产前评估与出生结局研究。

横向课题

1.4

2025-2027

王红梅

自主临床情景模拟与PBL相结合的教学方法在产科临床教学中的应用。

2020年院本科教学改革研究项目

1

2021.01-2022.01

张春华

“生育健康及妇女儿童健康保障”重点专项课题四：综合利用人工智能等技术，建立早产预测及临床诊疗策略模型。

国家重点研发计划

30

2022.10.30-2025.10.30

张春华

FGR胎儿及胎盘DNA甲基化调控的研究。

国家卫生健康委员会生育调控重点实验室横向课题

3

2021.06.01-2023.05.31

王燕芸

FGR胎儿及胎盘M6a RNA甲基化调控的研究。

横向课题

30

2022.11.01-2025.10.31

王燕芸

以临床指南为基础的产科典型病例库的建设及其在规培临床教学实践中的应用.

2020年院本科教学改革研究项目

1

2021.01-2022.01

宫伟雁

阿魏酸通过HIF-1调控滋养细胞焦亡预防子痫前期的机制研究

横向课题

3

2021.01

宫伟雁

METRNL改善炎症条件下滋养细胞功能预防子痫前期

国家卫生健康委生育调控重点实验室横向课题

15

2021.06.01-2023.05.31

宫伟雁

纳米载体靶向输送miRNAs反义核酸用于子痫前期治疗的实验研究

国家自然科学基金面上项目

53

2020.01-2023.12

李磊

优化严重产后出血诊治策略的研究

国家重点研发计划项目子课题

50

2021.12-2024.11

顾永忠

基于MRI的胎盘植入性疾病手术风险评分系统的构建及应用

济南市临床医学科技创新计划

10

2023.06-2026.05

顾永忠

改良球囊提拉宫颈缝合术在凶险性前置胎盘剖宫产中的应用

医疗技术创新激励项目

5

2022.02-2025.01

顾永忠

YBI通过miR-200b-3p/PFN2轴调控胎盘滋养细胞功能在子痫前期发病中的作用及机制研究

横向课题

30

2025.10.30-2027.10.30

刘惠君

利用孕妇外周血胎儿游离DNA含量建立重度子痫前期预测模型。

横向课题

30.1

2023.12-2026.12

王云霞

产时超声与产房可视化技术研究

科技部外专司项目 

15

2023-2025

刘霄

中性粒细胞胞外诱捕网通过HMGB1增加胎盘炎症反应促进子痫前期发生

山东省自然科学基金青年项目

15

2022.1-2024.12

卢媛

血栓调节蛋白通过靶向来自中性粒细胞胞外诱捕网的HMGB1改善子痫前期妊娠结局

国家卫生和计划生育委员会生育调控技术重点实验室开放课题

3

2021.06-2023.05

卢媛

Denndla 在小鼠胚胎发育中的作用。

省自然青年基金

15

2024.01-2026.12

石婧婧

TBPL2 基因突变在卵母细胞成熟障碍中的作用及机制研究

山东省自然科学基金青年项目

15

2023.1.1-2025.12.30

杨萍

ZP2基因突变在卵母细胞成熟障碍中的作用及机制研究

山东省立医院科研孵育基金

2

2022.1-2023.12

杨萍

胎盘滋养细胞来源外泌体miR- 107 在妊娠期糖尿病介导的胎儿肺发育不良中的作用机制研究

山东省立医院科研孵育基金

2

2024-2025

陈鹏正

胎盘滋养细胞来源外泌体miR-185-5p 介导妊娠期糖尿病胎儿肺发育不良的作用机制研究

山东省自然青年

8

2025-2027

陈鹏正

ANG/PLXNB2 轴在子痫前期胎盘形成过程中的

作用及机制研究

山东省自然青年

8

2025-2027

王羲尧

PLXNB2 在不明原因复发性流产中的作用。

山东省立医院科研孵育基金

2

2024-2025

王羲尧

PARP抑制剂诱导卵巢癌细胞焦亡的机制探索

山东省立医院科研孵育基金

2

2024-2025

黄璞

2025

Hydroxychloroquine confers placental protection in antiphospholipid Syndrome: Mechanistic insights into autophagy regulation and trophoblast dysfunction.

Biochem Biophys Res Commun. 2025 Jul 12;770:151994.

2.5

/王谢桐

2025

Gestational Exposure to Black Phosphorus Nanoparticles Induces Placental Trophoblast Dysfunction by Triggering Reactive Oxygen Species-Regulated Mitophagy.

 ACS Nano. 2025 May 6;19(17):16517-16533. 

15.8

/王谢桐

2025

Neutrophil extracellular traps aggravate placental injury in OAPS by facilitating activation of BNIP3 mediated mitophagy.

Free Radic Biol Med. 2025 Aug 1;235:109-123. 

7.1

/王谢桐

2025

The value of ultrasound indicators in early pregnancy for predicting selective intrauterine growth restriction and twin-twin transfusion syndrome: a case‒control study.

 BMC Pregnancy Childbirth. 2025 Feb 26;25(1)

2.8

/王玉立、王谢桐、李磊

2025

The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia.

FASEB J. 2025 Jun 15;39(11)

4.4

/王谢桐

2025

 The clinic application of mNGS and ENA-78 assays to identify intra-amniotic infection/inflammation.

Front Cell Infect Microbiol. 2025 Apr 4

4

/王谢桐

2025

MRI Signs Associated With Bladder Injury During Cesarean Delivery in Severe Placenta Accreta Spectrum Disorders

 J Magn Reson Imaging. 2025 Jul;62(1)

3.3

/王谢桐

2025

Anti-β2GPI antibodies induce trophoblast pyroptosis and placental inflammation through TLR4/NLRP3/GSDMD axis.

Placenta. 2025 Oct

2.5

张红媛/陈鹏正、王谢桐

2025

NETs exacerbate placental inflammation and injury through high mobility group protein B1 during preeclampsia.

Placenta. 2025 Jan;159:131-139.

3

/卢媛、王谢桐

2025

Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis.

 Front Immunol. 2025 Sep 19

5.09

/王谢桐

2025

Mechanism of hydroxychloroquine in the treatment of obstetric antiphospholipid syndrome by inhibiting NETs-induced trophoblast pyroptosis.

Mol Biol Rep. 2025 Jul 7;52(1):679.

2.8

/王谢桐

2025

TIGAR deficiency exacerbated preeclampsia by impairing autophagy and accelerating trophoblasts apoptosis upon excessive oxidative stress via the NRF2-ARE pathway.

 Life Sci. 2025 Dec 15

5.1

/王谢桐

2025

Prophylactic uterine artery embolization in second-trimester pregnancy termination with placenta previa and accreta spectrum after prior cesarean delivery: a retrospective cohort study.  

BMC Pregnancy Childbirth. 

2.7

顾永忠/彭文、王谢桐

2025

Whole transcriptome analysis and preliminary construction of ceRNA networks in obstetric antiphospholipid syndrome.

Front Immunol. 2025 Dec 8;

5.9

/ 陈鹏正、王谢桐

2025

Downregulated miR-199a-3p in Preeclamptic Placenta-derived Exosomes from Cord Blood Hinders VEGF-induced Fetal Glomerular Dysplasia Through Inhibiting Akt1(S473) Phosphorylation via Targeting PHLPP2.

Stem Cell Rev Rep. 2025 Nov;21(8):2693-2710

4.2

/周宇、王谢桐、李磊

2025

Role of Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia.

Am J Reprod Immunol. 2025 Jan

3.777

/孟金来

2025

Empty follicle syndrome: underlying etiology and precise treatment.

Trends Mol Med. 2025 Sep 30:S1471-4914(25)00210-2.

13.8

杨萍

2025

Risk factors for emergency cesarean delivery in patients with placenta accreta spectrum: a multicenter retrospective cohort study.

Front Med (Lausanne). 2025 Sep 3;

2.9

张红媛/

2025

M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the TXNIP/NLRP3 axis.

Life Sci. 2025 Jun 1

5.1

张红媛/陈鹏正、李磊、王谢桐

2025

Knockdown of HSF1 inhibits invasion, metastasis, and proliferation of endometrial carcinoma cells while promoting apoptosis

Cancer Biomarkers vol.42(4):1-11

3.83

刘海霞/王谢桐

2025

MiR-30d-5p Modulates Glucose and Lipid Metabolism by Targeting CD73 through the AMPK Pathway.

Cell Biochem Biophys. 2025 Dec;83(4):4947-4960.

2.5

/刘菁

2025

第二产程中产时超声对分娩方式的预测价值[J].

中国妇幼保健,2025,40(19):3668-3672

刘霄/王谢桐

2025

应用产时超声预测第二产程时长的可行性研究[J].

实用妇产科杂志,2025,41(6):496-500.

刘霄/王谢桐

2025

胎盘植入性疾病发病机制的研究进展

现代妇产科进展,2025,34(2):147-149,

/孟金来

2025

妊娠期隔离肺破裂致血气胸1例

中华围产医学杂志,2025,28(4)

/张春华

2024

The protective mechanism of human umbilical cord mesenchymal stem cell-derived exosomes against neutrophil extracellular trap-induced placental damage.

Placenta.

3

/王谢桐

2024

A De novo Mutation in the COL1A1 Gene Leading to Severe Osteogenesis Imperfecta: Case Report and Review of the Literature.

 AJP Rep.

0.8

/王谢桐

2024

Hsa-miR-3928-3p targets the CCL3/CCR5 axis to induce amniotic epithelial cell senescence involved in labor initiation.

Placenta. 2024 Oct;156:98-107.

3

/王谢桐、李磊

2024

miR-548az-5p induces amniotic epithelial cell senescence by regulating KATNAL1 expression in labor. Sci Rep.

2024 Dec 5;14(1):30380.

3.8

/王谢桐、李磊

2024

Simvastatin ameliorates adverse pregnancy by inhibiting glycolysis-related NETs in obstetrical antiphospholipid syndrome.

Life Sci. 2024 Dec 15;359:123215.

5.2

霍瑞恒/李磊王谢桐

2024

NETs exacerbate placental inflammation and injury 1 through high mobility group protein B1 during 2 preeclampsia

 Placenta. 2025 Jan;159:131-139.

3

/王谢桐

2024

PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF-caspase 8-GSDMD/E axis in ovarian cancer.

J Immunother Cancer. 2024 Oct 4;12(10):e009032.

10.9

黄璞/

2024

High expression of CX3CL1/CX3CR1 at the mother-fetus interface of preeclampsia inhibits trophoblast invasion and migration.

Placenta. 2024 Oct;156:30-37.

3

刘海霞/孟金来

2024

The PD-1 /PD-L1 signaling pathway regulates decidual macrophage polarization and may participate in preeclampsia.

J Reprod Immunol. 2024 Aug;164:104258.

2.9

/孟金来

2024

Nanopore-based metagenomics analysis reveals microbial presence in amniotic fluid: A prospective study.

 Heliyon.

4.2

钟立航/王谢桐

2024

Clinicopathologic characteristics and prognostic factors of patients with surgically treated high-grade neuroendocrine carcinoma of the cervix: A multicenter retrospective study.

Int J Gynaecol Obstet. 2024 Dec;167(3):1055-1065.

3.1

刘海霞/

2024

Decidual macrophage: a reversible role in immunotolerance between mother and fetus during pregnancy.

Arch Gynecol Obstet. 2024 May;309(5):1735-1744.

2.1

/李磊

2024

Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia.

J Assist Reprod Genet. 2024 May;41(5):1403-1416.

3.2

/李磊

2024

The role of aryl hydrocarbon receptors in nutrient metabolism and immune regulation at the maternal-fetal interface. Placenta.

2024 Sep 2;154:9-17.

3

/李磊

2024

Risk Factors Associated with Low Apgar Scores in Pregnancies

Complicated by Severe Preeclampsia: A Case–Control Study

Clin. Exp. Obstet. Gynecol. 2024; 51(12): 264

0.4

王云霞/孟金来

2024

Early identification and conservative treatment of postpartum hemorrhage in the lower uterine segment after vaginal delivery.

J Matern Fetal Neonatal Med. 2024Dec;3(1):2386081.

1.7

刘霄/王红梅

2024

如何避免产后出血的初次干预失败

实用妇产科杂志,2024,40(3):173-176.

顾永忠/王谢桐

2024

上腹部占位的孕妇确诊为糖原累积症Ⅰa型1例

山东大学学报（医版）,2024,62(5):121-124.

/张红媛

2024

抗病毒药物在产科的应用

实用妇产科杂志,2024,40(6):440-443.

/王谢桐

2024

产科快速反应团队成功救治心脏骤停孕产妇1例并文献复习

中华妇幼临床医学杂志（电子版）,2024,20(2):148-156.

/顾永忠

2024

抗病毒药物在产科的应用

实用妇产科杂志,2024,40(6):440-443.

/王谢桐

2024

上腹部占位的孕妇确诊为糖原累积症Ⅰa型1例

山东大学学报（医版）,2024,62(5):121-124.

/张红媛

2024

如何避免产后出血的初次干预失败

实用妇产科杂志,2024,40(3):173-176.

顾永忠/王谢桐

2023

Gestational Diabetes Mellitus Impedes Fetal Lung Development Through Exosome-Dependent Crosstalk Between Trophoblasts and Lung Epithelial Cells.

 Int J Nanomedicine. 2023 Feb 8;18:641-657.

7.033

陈鹏正/李磊、王谢桐

2023

 Effect of peroxiredoxin 1 on the regulation of trophoblast function by affecting autophagy and oxidative stress in preeclampsia.

J Assist Reprod Genet. 2023 Jul;40(7):1573-1587.

3.763

/王谢桐

2023

6-Gingerol alleviates placental injury in preeclampsia by inhibiting oxidative stress via BNIP3/LC3 signaling-mediated trophoblast mitophagy.

Front Pharmacol. 2023 Oct 13;14:1243734.

5.6

/王谢桐

2023

NETs promote ROS production to induce human amniotic epithelial cell apoptosis via ERK1/2 signaling in spontaneous preterm birth.

 Am J Reprod Immunol. 2023 Mar;89(3):e13656.

3.6

/王谢桐

2023

PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.

 Elife. 2023 Sep 22;12:e85944. 

7.7

/王谢桐

2023

 Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis. .

J Nanobiotechnology. 2023 Nov 13;21(1):419. doi: 10.1186/s12951-023-02179-5. PMID: 37957714; PMCID: PMC10641965

10.2

/王谢桐

2023

 Preeclampsia

impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial

cells.

 Cell Commun Signal. 2023;21(1):336.

8.4

/王谢桐、李磊

2023

Distinct cytokine profiles in patients with preeclampsia.

Inflamm Res. 2023 Apr;72(4):847-858.

6.986

/孟金来

2023

Single-cell transcriptomics dissects epithelial heterogeneity in HPV+ cervical adenocarcinoma.

J Med Virol. 2023 Feb;95(2):e28480. doi: 10.1002/jmv.28480. PMID: 36609919.

20.693

/李磊

2023

Excessive Immune Activation and the Correlation with Decreased Expression of PD-1 at the Maternal-Fetal Interface in Preeclampsia.   

Reprod Sci. 2023 Jan;30(1):192-202. doi: 10.1007/s43032-022-01003-z. Epub 2022 Jun 16.

3.06

/孟金来

2023

 MiR-218-5p promotes trophoblast infiltration and inhibits endoplasmic reticulum/oxidative stress by reducing UBE3A-mediated degradation of SATB1.

 J Cell Commun Signal. 2023 Sep;17(3):993-1008

3.9

孙晓梅/李磊

2023

Association between Plasma Protein C Activity and Adverse Pregnancy

Outcome in Pregnant Women: A Retrospective Cohort Study.

Clin. Exp. Obstet. Gynecol. 2023; 50(11): 242

0.2

王红梅/

2023

Correlative increasing expressions of KIF5b and Nav1.7 in DRG neurons of rats under neuropathic pain conditions.

 Physiol Behav. 2023 May 1;263:114115.

3.74

刘海霞/

2023

妊娠早期巨大子宫肌瘤术后分娩1例并文献复习

山东大学学报(医学版),2023,(第1期).

张红媛/顾永忠

2023

产科47例子宫切除的临床分析

山东大学学报（医学版）,2023,61(7):96-100. DOI:10.6040/j.issn.1671-7554.0.2023.0138.

张红媛/顾永忠

2023

母胎界面巨噬细胞在子痫前期发病机制中的作用

现代免疫学,2023,04:351-355+360.

 /孟金来

2023

产科抗磷脂综合征的管理[J].

实用妇产科杂志,2023,39(12):893-896.

/王谢桐

2023

再谈妊娠期TORCH筛查[J]

.实用妇产科杂志,2023,39(2):90-93.

李磊/王谢桐